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Old 12-06-2017, 11:06 PM
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Doxybene is associated with craving and tolerance development.
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Doxybene may rarely be habit forming. Doxybene should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Doxybene and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Doxybene and M1, respectively.
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In general, both enantiomers of Doxybene and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The binding of Doxybene to human plasma proteins is approximately 20%,
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Doxybene has not been shown to cause histamine release. At therapeutic doses, Doxybene has no effect on heart rate,
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Doxybene 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
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A single i.m. dose of Doxybene is useful pre-treatment to minimize the risk of acid aspiration during operation,
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Doxybene is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Check the label on the medicine for exact dosing instructions.Doxybene may cause drowsiness and dizziness.
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Although Doxybene is known to exhibit a local anaesthetic effect, how Doxybene exerts this effect is not understood fully.
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